Sepia officinalis ink mitigates gastric ulcer via modulation of antioxidant/anti-inflammatory pathways

Abstract Background Sepia officinalis ink is a bioactive secondary metabolite rich in melanin granules, which has wide range of nutritional and therapeutic values also been used to prevent various gastrointestinal disorders. Gastric ulcer, the most common disease, characterized by severe gastric mucosa damage, its prevention currently one main goals clinical experimental studies. Thus, present study was focused on evaluating potential gastroprotective efficacy extract (SOIE) against ethanol-induced ulcer rats. Results The current results revealed that SOIE administration at two selected doses improved significantly integrity as indicated significant ( P < 0.05) amelioration secretion indices (pH volume) marked decrease index. Moreover, could counteract oxidative stress induced ethanol via decline malondialdehyde content well increment glutathione antioxidant enzymes activities (catalase glutathione-s-transferase). Additionally, treatment caused reduction nitric oxide content. Respecting morphological histopathological studies, 200 mg/kg body weight healing lesions no hemorrhagic bands or injuries observed reduced severity score ulcer. Conclusions be promising alternative antiulcerogenic compound treat lesions.